Abstract

This manuscript explores the intricate relationships between opacification in the nasal sinuses, rhinosinusitis, and antiresorptive agent-related osteonecrosis of the jaw (ARONJ). Nasal sinus opacification, a common radiographic finding, can be associated with various underlying pathologies, including rhinosinusitis and ARONJ. Rhinosinusitis, characterized by inflammation of the paranasal sinuses, presents with symptoms such as nasal congestion, facial pain, and purulent nasal discharge. ARONJ, a severe complication of antiresorptive therapy, is characterized by the presence of exposed bone in the maxillofacial region. Understanding the relationships between these entities is crucial for accurate diagnosis and appropriate management. This manuscript reviews the epidemiology, pathophysiology, clinical manifestations, diagnostic modalities, and treatment options for nasal sinus opacification, rhinosinusitis, and ARONJ. Furthermore, it discusses the potential mechanisms underlying the association between nasal sinus opacification and ARONJ, highlighting the importance of interdisciplinary collaboration between otolaryngologists, dentists, and oncologists in the comprehensive management of patients at risk.