Abstract

Acute necrotizing encephalopathy (ANE) is a rare condition mainly affecting children with a distinct clinicradiologic pattern. Initially thought to be secondary to respiratory viral infections, there have been more insights into the pathogenesis of ANE, including genetics. We present 2 cases of adults who developed this condition with classical clinic-radiologic findings of ANE secondary to severe dengue infection and could not survive. We report these cases intending to raise awareness about this fatal complication of dengue infection, as dengue has become a global healthcare problem.