Abstract

Radiotherapy is traditionally recognized for its role in cancer treatment, leveraging high-energy rays to target and destroy cancer cells. While its primary application is in oncology, recent studies have explored its efficacy in treating non-cancerous conditions. This review focuses on the use of radiotherapy in managing Dupuytren's disease and Ledderhose disease, both of which are fibrotic disorders that can significantly impact quality of life. Radiotherapy, typically employed to damage the DNA of malignant cells, has been shown to effectively reduce the progression of fibrosis in these benign conditions. By examining clinical trials, patient outcomes, and treatment protocols, this review aims to provide a comprehensive overview of how radiotherapy can be adapted to treat these non-cancerous diseases. It also discusses the underlying mechanisms of action, including the modulation of fibrotic processes and the potential for reducing the need for invasive surgical interventions. The findings highlight radiotherapy's versatility and its potential to offer significant benefits in the management of conditions beyond cancer.