Abstract

Giant Cell Reparative Granuloma (GCRG) presents a diagnostic conundrum due to its diverse clinical and radiographic manifestations. This study investigates the intricate interplay between radiographic imaging and histopathological analysis in GCRG diagnosis and management. Radiographically, GCRG typically appears as a well-defined osteolytic lesion with a characteristic “soap bubble” or “honeycomb” appearance, often accompanied by cortical thinning or perforation. Computed tomography (CT) scans reveal a multilocular lesion with thin septations and areas of hemorrhage or cystic change. Histopathologically, GCRG is characterized by a proliferation of multinucleated giant cells within a fibroblastic stroma, occasionally interspersed with osteoid formation and areas of hemorrhage. Although this histological pattern is characteristic, variations can complicate diagnosis, necessitating differentiation from other giant cell-containing lesions such as central giant cell granuloma and aneurysmal bone cyst. The correlation between radiographic features and histopathological findings is pivotal for accurate diagnosis and tailored management strategies. Surgical excision remains the mainstay of treatment for symptomatic GCRG, with adjunctive therapies such as intralesional corticosteroid injections and denosumab showing promise in select cases. Further research is warranted to elucidate the molecular mechanisms underlying GCRG pathogenesis and to refine diagnostic algorithms for improved patient outcomes. Understanding the radiographic-histopathological correlation in GCRG enhances diagnostic precision, facilitates appropriate treatment selection, and optimizes patient care