Progress on the Long Non-coding RNAs Involved in Alzheimer’s Disease
Received Date: Jan 17, 2024 / Published Date: Feb 19, 2024
Abstract
Alzheimer’s Disease (AD) is terminal and is considered the most common neurodegenerative disease characterized by progressive memory loss and cognitive impairment, accounting for 60% of all dementia cases. AD has been widely studied, but its pathological mechanism is still unclear. Noncoding RNAs (ncRNAs) are a class of RNAs that do not encode proteins. Increasing evidence has indicated that long noncoding RNAs (lncRNAs) play essential roles in protein coding processes, biological activities and various diseases, including AD. This study aims to highlight the emerging roles of lncRNAs in AD by summarizing current studies about lncRNAs as potential biomarkers, the roles of lncRNAs involved in Aβ plaque formation, tau hyperphosphorylation, microglia and astrocyte activation, NLRP3 inflammation and oxidative stress. Finally, we tried to elucidate the possible mechanisms by which lncRNAs function and provide new ideas for the diagnosis and treatment of AD.
Keywords: Long noncoding RNA; Alzheimer’s disease; Biomarker; Biological roles
Citation: Aodeng Q, Su D, Bai Y, Yang X.X, Wuhan Q (2024) Progress on the Long Non-coding RNAs involved in Alzheimer’s Disease. Cell Mol Biol S1:001.
Copyright: © 2024 Aodeng Qimuge et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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