Abstract

Advancements in biomimetic biomaterials have revolutionized the field of endogenous skin regeneration by mimicking the natural extracellular matrix (ECM) and cellular interactions crucial for tissue repair. This abstract explores the development and applications of biomimetic biomaterials tailored to enhance skin regeneration through mechanisms that promote cellular adhesion, proliferation, and differentiation. Key advancements include the synthesis of biomaterials that replicate the structural and biochemical cues of native ECM components, such as collagen, elastin, and glycosaminoglycan .These biomaterials support the attachment and growth of keratinocytes, fibroblasts, and endothelial cells, fostering tissue remodeling and vascularization essential for wound healing. Applications of biomimetic biomaterials range from topical dressings and scaffolds for chronic wound management to engineered skin substitutes for severe burns and trauma. Clinical studies have demonstrated their efficacy in accelerating wound closure, reducing scar formation, and restoring skin function, highlighting their potential in regenerative medicine. Furthermore, the abstract discusses future directions in biomimetic biomaterial research, including bioactive modifications, personalized therapies, and integration with advanced biotechnologies to optimize skin regeneration outcomes and address clinical challenges. In conclusion, biomimetic biomaterials represent a promising strategy for endogenous skin regeneration, offering innovative solutions to enhance healing processes and improve patient outcomes in dermatology and wound care.