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Primary Immunodeficiency in Africa, a Case for Autopsy Based Implementation Science Projects
| Edwin Walong and Anne Barasa* | ||
| Department of Human Pathology, School of Medicine, University of Nairobi, Nairobi, Kenya | ||
| Corresponding Author : | Anne Barasa Department of Human Pathology School of Medicine, University of Nairobi, Nairobi, Kenya Tel: 0738-590623 E-mail: edwin.walong@gmail.com |
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| Received July 21, 2014; Accepted March 18, 2015; Published March 25, 2015 | ||
| Citation: Walong E, Barasa A (2015) Primary Immunodeficiency in Africa, a Case for Autopsy Based Implementation Science Projects. J Infect Dis Ther 3:205. doi:10.4172/2332-0877.1000205 | ||
| Copyright: © 2015 Walong E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | ||
Related article at Pubmed Scholar Google |
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Abstract
Primary immunodeficiency encompasses a broad range of constitutional innate and adaptive immune dysfunction characterised by recurrent or severe infections. In developing countries in sub-Saharan Africa there are high rates of infectious disease morbidity and mortality. Low autopsy rates, inadequate diagnostic infrastructure limits the diagnosis and characterisation of primary immunodeficiency. Targeted implementation science approaches to clinical autopsy in developing sub-Saharan countries would evaluate the magnitude of this problem and provide innovative diagnostic approaches.
