ISSN: 2381-8727

International Journal of Inflammation, Cancer and Integrative Therapy
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  • Int J Inflam Cancer Integr Ther,
  • DOI: 10.4172/2381-8727.1000205

Prenatal Inflammation Disrupts Murine Foetal Hematopoietic Development and Alters Postnatal Immunity

Annie Beudin*
Department of Internal Medicine and Pathology, and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, UT, U.S.A
*Corresponding Author : Annie Beudin, Department of Internal Medicine and Pathology, and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, UT, U.S.A, Email: annie.beudin@hsc.utah.edu

Received Date: Jan 25, 2023 / Published Date: Feb 28, 2023

Abstract

Adult hematopoietic stem and progenitor cells (HSPCs) respond directly to inflammation and infection, changing their quiescence, mobilisation, and differentiation in both acute and chronic ways. We show that murine foetal HSPCs respond in utero to prenatal inflammation, and that this response shapes postnatal hematopoiesis and immune cell function. Divergent responses of heterogeneous foetal HSPCs to maternal immune activation (MIA) include changes in quiescence, expansion, and lineage-biased output [1 ]. In response to MIA, single-cell transcriptomic analysis of foetal HSPCs reveals specific upregulation of inflammatory gene profiles in discrete, transient hematopoietic stem cell (HSC) populations that propagate expansion of lymphoid-biased progenitors. MIA causes inappropriate postnatal expansion and persistence of foetal lymphoid-biased progenitors, as well as increased cellularity and hyperresponsiveness of fetal-derived innate-like lymphocytes. By reshaping foetal HSC establishment, we show how inflammation in utero can direct the output and function of fetal-derived immune cells [2].

Citation: Beudin A (2023) Prenatal Inflammation Disrupts Murine FoetalHematopoietic Development and Alters Postnatal Immunity. Int J Inflam CancerIntegr Ther, 10: 205. Doi: 10.4172/2381-8727.1000205

Copyright: © 2023 Beudin A. This is an open-access article distributed under theterms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author andsource are credited.

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