Abstract

Sinonasal manifestations in pediatric cystic fibrosis (CF) patients pose significant challenges in management and prognosis. This manuscript explores the predictors associated with the onset, progression, and severity of sinonasal ailments in children afflicted with CF. A comprehensive review of literature, including epidemiological studies, clinical trials, and retrospective analyses, was conducted to elucidate the multifactorial nature of sinonasal complications in CF. The findings highlight the interplay between genetic predisposition, environmental factors, microbial colonization, mucociliary dysfunction, and inflammatory processes in the development and exacerbation of sinonasal ailments in this population. Understanding these predictors is imperative for optimizing preventive strategies, diagnostic approaches, and therapeutic interventions tailored to the unique needs of pediatric CF patients.