Predictive Value of the TSH/FT4 Ratio in Women with Suspected PE or GH
Received Date: Oct 19, 2017 / Accepted Date: Nov 02, 2017 / Published Date: Nov 09, 2017
Abstract
Objective: In the present study, we aimed to examine whether the TSH/FT4 ratio after the second trimester can predict the prevalence of preeclampsia (PE) or gestational hypertension (GH).
Study design: Retrospective case-control study.
Methods: We collected TSH and FT4 serum levels after the second trimester in 133 pregnant women with suspected PE or GH. Participants were divided into 2 groups, the PE+GH group and the non-PE+GH group and conducted the retrospective study for the two groups to evaluate the background and the prevalence of PE or GH were retrospectively evaluated.
Results: Among the participants in the PE+GH group, mean age, body mass index (BMI) at no pregnancy and BMI at delivery were 34.5 ± 6.7 years, 22.3 ± 3.9 kg/m2 and 26.0 ± 4.0 kg/m2, respectively. Among the participants in the non-PE+GH group, mean age, BMI at no pregnancy and BMI at delivery were 32.9 ± 5.5 years, 22.5 ± 4.8 kg/m2 and 26.1 ± 4.4 kg/m2, respectively. There were no significant differences observed between the two groups. The cutoff point of the TSH/FT4 ratio was 1.9 (sensitivity 0.45, specificity 0.81), which was derived from the receiver operating characteristic curve. The adjusted odds ratio of PE or GH prevalence was 3.60 (95% CI: 1.62-8.02).
Conclusion: The TSH/FT4 ratio after the second trimester may aid in the prediction of PE or GH prevalence.
Keywords: Preeclampsia; Gestational hypertension; TSH; FT4
Citation: Fudaba M, Tanaka K, Matuski A, Komori M, Matsuki T, et al. (2017) Predictive Value of the TSH/FT4 Ratio in Women with Suspected PE or GH. J Preg Child Health 4: 357. Doi: 10.4172/2376-127X.1000357
Copyright: ©2017 Fudaba M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
