Abstract

This study explores the transcriptomic differences in the sub-acromial bursa of patients with rotator cuff tears, both with and without adhesive capsulitis. Using RNA sequencing, we analyzed tissue samples from 30 patients to identify differentially expressed genes and potential molecular biomarkers associated with these conditions. The results revealed distinct transcriptomic profiles, highlighting several upregulated and downregulated genes specific to each group. Notably, pathways related to inflammation, fibrosis, and healing were significantly altered in patients with adhesive capsulitis. These findings suggest that the sub-acromial bursa may play a critical role in the pathophysiology of rotator cuff tears and adhesive capsulitis, potentially offering targets for therapeutic intervention. The identified molecular biomarkers could serve as valuable indicators for diagnosis and treatment strategies, paving the way for personalized approaches in managing shoulder disorders. Further research is needed to validate these biomarkers and elucidate their functional roles in disease progression.