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Hindi Editorial
Potential Drug Targets in the Death Pathway: Therapeutic Approaches in Apoptosis
| Md. Salahuddin1*, Md. Shariful Islam2, Abu Zaffar Shibly2, Hasibul Haque Rakib2, Muhammad Jahangir Hossen3, Md. Ramim Tanver Rahman4, MA Momin5, Md. Sayfullah Razin6, Jay Prakash Sah7, Md. Abdur Rahman8, Muhammad Aurang Zeb9 and Mizanur Rahman Washim10 | |
| 1Faculty of Medicine, University of Hongkong, Pokfulam Road, Hongkong | |
| 2Department of Biotechnology and Genetic Engineering, Faculty of Life science, Mawlana Bhashani Science and Technology University, Tangail-1902, Bangladesh | |
| 3Department of Animal Science, Patuakhali Science and Technology University, Bangladesh | |
| 4National Engineering research Centre for functional Food, Jiangnan University, Wuxi 214122, PR China | |
| 5Department of Microbiology, Faculty of Veterinary Medicine, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh | |
| 6College of Medicine, Shaheed Ziaur Rahman Medical College, Bogra, University of Rajshahi, Bangladesh | |
| 7Department of Medical Laboratory Science, School of Health and Allied Sciences, Pokhara University, Lekhnath -12 Kaski, Nepal | |
| 8Faculty of veterinary Medicine, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh | |
| 9Department of Biochemistry, Hazara University, Mansehra, Khyber Pakhtunkhwa, Pakistan | |
| 10Bangladesh Fisheries research Institute, Mymensing, Bangladesh | |
| Corresponding Author : | Md. Salahuddin PhD Research Fellow Faculty of Medicine, University of Hongkong Pokfulam Road, Hongkong Tel: +852-5584- 1096 E-mail: ssdin23@gmail.com |
| Received: October 26, 2015; Accepted: October 27, 2015; Published: November 03, 2015 | |
| Citation: Salahuddin M, Shariful Islam M, Shibly AZ, Rakib HH, Hossen MJ, et al. (2015) Potential Drug Targets in the Death Pathway: Therapeutic Approaches in Apoptosis. Biochem Physiol 4:e141. doi:10.4172/2168-9652.1000e141 | |
| Copyright: © 2015 Salahuddin M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
Abstract
The form of programmed cell death known as Apoptosis has become an intense focus of investigation in various fields including carcinogenesis and cancer therapy. It is a sequentially regulated suicidal programme where cells regulate certain enzymes including caspase 9 activation and cytochrome C release with apoptosis inducing factor (AIF). The Bcl-2 proteins also represent a promising target for modulating tumor cell sensitivity to Apoptosis. Disturbance of this regulatory pathway may lead to various diseases like autoimmune diseases, neurodegenerative diseases and cancers. Therefore, understanding the mechanisms for apoptosis signaling pathway will give us huge knowledge to enlighten the pathogenesis of various diseases including cancer, and will open new horizons to therapeutic approaches in drug designing.
