Post-Transplant Lymphoproliferative Disorders after Allogeneic Hematopoietic Stem Cell Transplantation: Case Report and Literature Review
Received Date: Aug 31, 2021 / Accepted Date: Sep 14, 2021 / Published Date: Sep 21, 2021
Abstract
PTLDs are disorders with a spectrum ranging from “early” polyclonal proliferations resembling nonspecific plasma cell hyperplasia or infectious mononucleosis to clonal proliferations of B or T/NK cells. The incidence of PTLD after HSCT is approximately 0.8%-4.0%. The clinical manifestations of PTLD are variable related to the morphological types, sites, and patient’s general condition. Four basic histological types of PTLD have been identified: Nondestructive PTLD, polymorphic PTLD, monomorphic PTLD and classical Hodgkin Lymphoma. Treatments for PTLD comprise reduction of immunosuppression, rituximab, chemotherapy, and adoptive immunotherapy.
Keywords: Hematopoietic stem cell transplantation; Post-transplant lymphoproliferative disorders; Leukemia; Epstein-Barr virus
Citation: Chen D, Jiang , Shen D (2021) Post-Transplant Lymphoproliferative Disorders After Allogeneic Hematopoietic Stem Case Report and Literature Review. J Clin Exp Pathol 11: 397.
Copyright: © 2021 Chen D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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