Abstract

Protein-protein interaction networks play a vital role in understanding cellular processes and their evolution. Positive selection and centrality are two important concepts in the study of PPI networks. Positive selection refers to the process by which beneficial genetic variations are favored and spread through a population, shaping protein interactions. Centrality measures, on the other hand, quantify the importance of individual proteins within a network based on their connectivity and influence. This article explores the concepts of positive selection and centrality in the PPI networks of yeast and fruit flies, highlighting their implications for evolutionary and systems biology.