Abstract

Polymorphic drug metabolism, characterized by genetic variability in drug-metabolizing enzymes, presents a fascinating and clinically significant aspect of pharmacology and personalized medicine. This phenomenon, particularly evident in enzymes of the cytochrome P450 superfamily, can lead to diverse drug responses among individuals. Understanding polymorphic drug metabolism is paramount for optimizing drug therapy, minimizing adverse reactions, and improving patient outcomes. This abstract provides a concise overview of polymorphic drug metabolism, highlighting its implications in clinical practice and the challenges associated with its implementation. The exploration of genetic variations in drug-metabolizing enzymes offers insights into individualized drug responses and underscores the importance of personalized medicine in modern healthcare.