PI3K/AKT/mTOR Pathway in ATLL: from Basic Biology to Preclinical Study
Received Date: Nov 26, 2018 / Accepted Date: Feb 12, 2019 / Published Date: Feb 18, 2019
Abstract
Adult T-cell leukemia/ lymphoma (ATLL) is high resistance fatal malignancy which has a poor prognosis and exhibits resistance to conventional chemotherapy. The development of novel therapies for ATLL relies on a comprehensive understanding of the occurrences that result in cellular survival and proliferation regulating pathways that control growth signals is an emerging and complementary approach to ATL treatment. The PI3K/AKT/mTOR is a pivotal gatekeeper for cell growth, viability, migration, proliferation, and development drug resistance. Activation of PI3K, AKT, mTOR regulates important genes and proteins like mTOR, p53, NF-κB, P27, P21, S6K, FKHR and BAD. So this rout has a central role in handling cell cycle regulators, transcription factors and anti-apoptotic proteins. This review focuses on the role of PI3K/AKT/mTOR in ATL progression and development drug resistance.
Keywords: PI3K; AKT; mTOR; HTLV-1; ATLL
Citation: Naghinezhad J (2019) PI3K/AKT/mTOR Pathway in ATLL: from Basic Biology to Preclinical Study. J Cell Mol Pharmacol 3: 104.
Copyright: © 2019 Naghinezhad J. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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