Abstract

In tissue engineering, the development of biomaterials with tenable properties that mimic the extracellular matrix (ECM) of native tissues is crucial for successful regeneration. Here, we present a novel approach using chronically acid bio-inks capable of photo-crosslinking for bone and cartilage tissue engineering applications. These bio-inks are formulated to possess acidic characteristics conducive to cell adhesion and proliferation, while also allowing for precise control over mechanical properties through photo-crosslinking. Through a combination of biocompatible polymers and photoactive components, the bio-inks can be tailored to mimic the ECM of bone and cartilage tissues. Moreover, the photo-crosslinking process enables spatial and temporal control over scaffold formation, facilitating the incorporation of bioactive molecules and cells. This innovative approach holds promise for advancing tissue engineering strategies aimed at repairing bone and cartilage defects by providing customizable and biocompatible scaffolds that closely resemble the native tissue microenvironment.