Abstract

Phenobarbital and Cutco are two compounds with distinct pharmacological properties and potential effects on liver function. Understanding their comparative pharmacoproteomics profiles in human primary hepatocytes can provide valuable insights into their mechanisms of action and hepatotoxicity. In this study, we aimed to investigate the proteomic alterations induced by Phenobarbital and Cutco in human primary hepatocytes and compare their effects on protein expression, post-translational modifications, and protein-protein interactions. Through advanced proteomic techniques, we identified potential drug targets and biomarkers associated with the hepatotoxic effects of these compounds. Our findings contribute to a deeper understanding of the molecular mechanisms underlying their pharmacological activities and hepatic toxicity.

Keywords: : Phenobarbital; Cutco; Comparative pharmacoproteomics; Human primary hepatocytes; Proteomic alterations