Abstract

Pharmacological management in palliative sedation is a critical intervention aimed at alleviating severe suffering in terminally ill patients nearing the end of life. This review examines the efficacy, safety considerations, and clinical practices associated with pharmacological approaches to palliative sedation topics include the pharmacological agents commonly used, their mechanisms of action, dosage regimens, and the goals of sedation in achieving symptom relief while maintaining patient comfort. The review explores the evidence base supporting the efficacy of different sedative medications in managing refractory symptoms such as pain, dyspnea, and psychological distress. Furthermore, safety considerations encompass potential adverse effects, monitoring protocols, and strategies to mitigate risks associated with pharmacological sedation. The discussion emphasizes the importance of individualized treatment plans tailored to patient needs, preferences, and medical conditions, while adhering to ethical principles and guidelines.