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Hindi Pharmacokinetics Analysis of Copen, a unique anticancer Semi artificial by-product of Osthole, in Rats when Intragastric and endovenous Administration
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Copyright: © 2019 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Copen is one in all of the key semi artificial derivatives of osthole with apparent anticancer interest. certainly the bioavailability and gender-related pharmacokinetic properties of copen in rats were decided during this look at. Sprague-Dawley rats were intragastrically and intravenously administrated of various doses of copen, severally. The concentrations of copen in rat plasma had been decided with the aid of a LC-MS/MS methodology. Pharmacokinetic parameters had been calculable employing a drug and statistics (DAS) software system. implemented mathematics analysis become carried out victimization freelance two-sample t-check with p-values but 0.05 due to the fact the level of significance. The outcomes indicated that maximum plasma concentrations (Cmax) for copen have been finished at nine.
