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Hindi Research Article
Pharmacokinetic Study of Zaltoprofen Spherical Agglomerated Dense Compacts Canvassed with Commercial Product
| Hari Krishna E1*, Rama Mohan Gupta V2 and Jyothi S1 | |
| 1Department of Pharmaceutics, CES College of Pharmacy, Kurnool, India | |
| 2Principal, Pulla Reddy Institute of Pharmacy, Dommadugu, Dundigal, Hyderabad, India | |
| Corresponding Author : | Hari Krishna E Associate Professor CES College of Pharmacy Kurnool-18, India Tel: 919948904629 E-mail: elluruharikrishna@gmail.com |
| Received January 08, 2013; Accepted January 28, 2013; Published February 01, 2013 | |
| Citation: Hari Krishna E, Rama Mohan Gupta V, Jyothi S (2013) Pharmacokinetic Study of Zaltoprofen Spherical Agglomerated Dense Compacts Canvassed with Commercial Product. Clinic Pharmacol Biopharm 2:107. doi:10.4172/2167-065X.1000107 | |
| Copyright: © 2013 Hari Krishna E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
Abstract
Pharmacokinetic parameters including AUC0-t, AUC0-∝, Cmax, Tmax, T1/2 and Elimination rate constant (Kel) were determined from plasma concentrations of Zaltoprofen spherical agglomerated dense compacts by 24 factorial design canvassed with a commercially available formulation of Zaltoprofen. Foremost spherical agglomerates of Zaltoprofen prepared with PEG 6000 which is hydrophilic polymer and evaluated for different compressibility parameters and in vitro dissolution studies, studies indicated that the drug release can be modulated by using hydrophilic polymers and the best one compressed as dense compacts and appraised for pharmacokinetic parameters in rabbit models. Sensitive and selective high performance liquid chromatographic method was used to determine drug plasma concentrations with good linearity in the range of 0.5 to 20 μg/mL (r2=0.995, n=7). Study ascertained meliorated values of AUC0-24 (15.789 ± 12.9, 97.334 ± 7.478).
