Pharmacogenomics in Pregnancy: Tailoring Drug Therapy for Maternal and Fetal Health
*Corresponding Author:Received Date: Apr 01, 2024 / Accepted Date: Apr 30, 2024 / Published Date: Apr 30, 2024
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Abstract
Pregnancy presents a unique challenge in drug therapy due to the dynamic physiological changes that impact
drug metabolism and response in both the mother and fetus. Pharmacogenomics offers a promising approach to
optimize medication management during pregnancy by elucidating genetic factors influencing drug metabolism,
efficacy, and safety. This abstract explores the role of pharmacogenomics in tailoring drug therapy for maternal and
fetal health. Genetic variations in drug-metabolizing enzymes, transporters, and targets can significantly affect drug
pharmacokinetics and pharmacodynamics, thus influencing individual responses to medications during pregnancy.
By integrating pharmacogenomic insights into prenatal care, clinicians can make informed decisions regarding drug
selection, dosing, and monitoring to minimize the risk of adverse reactions while maximizing therapeutic efficacy for
both the mother and fetus. Despite challenges such as the need for standardized testing protocols and interpretation
of genetic data, pharmacogenomics holds the promise of personalized medicine approaches in pregnancy, paving
the way for improved maternal and fetal outcomes. Embracing pharmacogenomic principles in prenatal care
represents a crucial step towards enhancing medication safety and effectiveness in pregnancy, ultimately benefiting
maternal and fetal health.