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Perspective of Andrographis paniculata in Neurological Disorders
| Vikas Kumar1*, Ajit Kumar Thakur1 and Shyam Sunder Chatterjee2 | |
| 1Neuropharmacology Research Laboratory, Department of Pharmaceutics, Indian Institute of Technology (Banaras Hindu University), Varanasi-221 005, India | |
| 2Retired Head of Pharmacology Research Laboratories, Dr. Willmar Schwabe GmbH & Co KG, Karlsruhe, Germany | |
| Corresponding Author : | Vikas Kumar Neuropharmacology Research Laboratory, Department of Pharmaceutics Indian Institute of Technology (Banaras Hindu University) Varanasi-221 005, India Tel: +91-542-6702742 Fax: +91-542-2368428 E-mail: vikas.phe@iitbhu.ac.in |
| Received March 16, 2014; Accepted April 15, 2014; Published April 20, 2014 | |
| Citation: Kumar V, Thakur AK, Chatterjee SS (2014) Perspective of Andrographis paniculata in Neurological Disorders. Clin Pharmacol Biopharm S2: 005. doi:10.4172/2167-065X.S2-005 | |
| Copyright: © 2014 Kumar V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
Abstract
Andrographis paniculata (Burm. F.) Wall. Ex Nees (Acanthaceae) is a labdane diterpinoids rich medicinal plant. Andrographolide is quantitatively the major bioactive secondary metabolite present in this herb. In Ayurveda, Andrographis paniculata is classified as a Rasayana herb. Several pre-clinical and well-controlled clinical trials performed during recent years have confirmed the therapeutic efficacies and broad safety profile of Andrographis paniculata as well as its secondary metabolites. Therefore, Andrographis paniculata seems to be another example of medicinal Ayurvedic plants which could not only be better explored for discovering structurally and functionally novel therapeutic leads, but also for identifying novel pharmacological principles and targets potentially useful for neurological disorders.
