Pelvic Girdle Myopathy Caused by Isotretinoin: Case Report and Discussion of Pathophysiology
Received Date: Jan 15, 2014 / Accepted Date: Feb 11, 2014 / Published Date: Feb 13, 2014
Abstract
Introduction: Isotretinoin is the mainstay therapy for severe and nodulocystic acne. Myalgia and muscle stiffness have been reported in 16-51% of patients treated with isotretinoin, while elevated serum Creatine Kinase (CK) levels have been found in up to 41%. In this paper, we report, for the first time, the occurrence of myopathy limited to the pelvic-girdle muscles in a teen who received isotretinoin therapy.
Methods: This was a case study conducted at King Khalid Hospital.
Results: Histopathology and other laboratory data were consistent with an inflammatory myopathy based on a vasculitic process.
Conclusion: Our data indicate that the myopathy caused by isotretinoin is an inflammatory process based on vasculitis, resulting in ischemic muscle necrosis.
Citation: Janati A, Naif AG, Ghorbel S, Al-Emadi BA, Al-Shurtan KS, et al. (2014) Pelvic Girdle Myopathy Caused by Isotretinoin: Case Report and Discussion of Pathophysiology. J Clin Exp Pathol 4:160. Doi: 10.4172/2161-0681.1000160
Copyright: © 2014 Ghorbel S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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