Abstract

The testing of human fetus mesencephalic tissues with intrastriatal transplantation clinically,that are rich in dopamine producing neurons. Parkinson’s disease patient showed cell transplantation works and in many cases produces impervious improvements. Due to the poor availability of tissues, this method could only be administered in fewer number of patients and acclimitization was very difficult,leads to immense deflection in operative outcomes. For transplantation, undifferentiated (stem) cells and special (reprogrammed) cells could be availed potentially to emoulument dopamine producing neurons.From human embryonic stem cells dopamine producing neurons that will be of the appropriate substantia nigra phenotype can be emolumented in larger numbers and soon will be ready for application in patients.Dopamine producing neurons obtained from pluripotent stem cells of human are supposed to be used for clinical transplantation. In a controlled clinical studies,the present data justifies leading in a way with these dopamine producing neurons, that should be tested by choosing desirable patients, anticipation of cell and methods of transplantation.

Keywords: Human fetus mesencephalic tissues; Dopamine producing neurons; Human pluripotent stem cells; Stem cells transplantation; Human embryonic stem cells; Reinnervation, Denervated striatum; Substantial nigra