Abstract

Parathyroid carcinoma is a very rare endocrine neoplasm which results high production of parathyroid hormone (PTH) responsible for pathologic high calcium levels resulting in bone pain/fractures, renal disease and other signs of hypercalcemia. Clinically the disease is detected in patients earlier important because the morbidity and mortality are significant and the best prognosis is associated with early diagnosis and surgical resection.

Here, we present a rare case of familial hyperparathyroidism in which he and his two sons were diagnosed. We report a case of a 59 year old male who presented to our hospital with persistent hyperparathyroidism and hypercalcemia 6 years after having undergone total of two parathyroidectomy operations in this hospital and another.

Development of parathyroid carcınoma in isolated familial primary hyperparathyroidism should be kept in mind. The primary treatment of parathyroid carcinoma on the basis of isolated familial hyperparathyroidism is surgery. When the tumor is no longer amenable to surgical intervention, treatment becomes focused on the control of hypercalcemia with medical therapy, which can include bisphosphonates, calcimimetic agents, or denosumab.