Papillary Thyroid Carcinoma with Prominent Hobnail Features Diagnosed Preoperatively by Fine Needle Aspiration and Demonstrating Constitutive Activation of mTOR Signaling Pathway: A Case Report
Received Date: Oct 23, 2013 / Accepted Date: Nov 28, 2013 / Published Date: Dec 02, 2013
Abstract
Papillary Thyroid Carcinoma (PTC) with prominent hobnail features is a recently recognized aggressive variant of PTC. The cytologic features and molecular characterization have not been fully investigated. We present a patient with a preoperative fine needle aspiration diagnosis of PTC with hobnail features that demonstrated constitutive activation of mTOR pathway with evidence of mTORC2 activation on immunohistochemical staining. These findings may be of value for clinical management, targeted therapy, and prognostication.
Keywords: Cytopathology, Fine needle aspiration, Hobnail variant, Immunohistochemistry, mTOR, Papillary thyroid carcinoma
Citation: Liu J, Brown RE, Rubenfeld S, Karni RJ (2013) Papillary Thyroid Carcinoma with Prominent Hobnail Features Diagnosed Preoperatively by Fine Needle Aspiration and Demonstrating Constitutive Activation of mTOR Signaling Pathway: A Case Report. J Clin Exp Pathol 4:152. Doi: 10.4172/2161-0681.1000152
Copyright: © 2013 Liu J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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