Abstract

The Plasmin is released as a zymogen called plasminogen (PLG) from the liver into the systemic circulation. Humans have two types of glycoforms for the plasminogen that is type-1 is comprised of N- linked (to N289) glycosylation and O-linked (to T346) glycosylation for type-2 plasminogen only consists of single Olinked sugar to T346. However, most of the cell surface favors type-2 plasminogen over the type-1 glycoform, whereas type-1 is
commonly found on the surface of the blood clots.