Abstract

EOC is typically caused by direct cell slipping from the primary excrescence into the intra-abdominal depression, which is filled with nasty ascitic effusions. Cells spread throughout the depression, astronomically seed and foray through peritoneal filling, and renew secondary excrescence growth in abdominal and pelvic organs, aided by fluid inflow. Cancer cells live within a multidimensional excrescence medium composed of intraperitoneally abiding cancer- reprogramed fibroblasts, adipose, vulnerable, mesenchymal stem, mesothelial, and vascular cells that ply eclectic bioactive motes into nasty ascites and contribute to EOC progression and metastasis via distinct molecular mechanisms and epigenetic dysregulation at all stages of this unique metastatic process.