Oral Human Papillomavirus (HPV) Infection in Healthy Individuals and Patients with Head and Neck Squamous Cell Carcinoma (HNSCC)
Received Date: Dec 14, 2014 / Accepted Date: Jan 12, 2015 / Published Date: Jan 15, 2015
Abstract
Human papillomavirus (HPV) infection is the most common sexually transmitted disease. It also contributes significantly to infection-associated human malignancies, including cervical, anal, penile, vaginal, and vulvar cancer as well as a subset of head and neck squamous cell carcinoma (HNSCC). Despite our extensive knowledge on the role of HPV in the etiology of cervical cancer, cervical cancer screening, prevention, and clinical management, we have just begun to appreciate the role of HPV in the tumorigenesis of HNSCC. In this paper, we will review our current knowledge on the natural history of oral HPV infection in the general population, risk factors for oral HPV infection, the presence of novel HPV types infecting oral cavity, limitations of existing methods for oral HPV detection and its application in the clinical setting. Finally, we will also discuss the role of HPV vaccine in preventing HNSCC.
Keywords: HPV infection; Head and neck squamous cell carcinoma (HNSCC); Oral HPV; oropharyngeal cancer; Prophylactic vaccine
Citation: Dang J, Manrique HXZ, Veron D, Feng Q (2015) Oral Human Papillomavirus (HPV) Infection in Healthy Individuals and Patients with Head and Neck Squamous Cell Carcinoma (HNSCC). Epidemiology(sunnyvale) 5:180. Doi: 10.4172/2161-1165.1000180
Copyright: © 2015 Dang J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
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