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Number of Circulating Apoptotic Endothelial Cell-Derived Micro Particles as a Predictor of Metabolically Unhealthy Obesity
1Private Medical Center “Vita-Center”, Zaporozhye, Ukraine
2Internal Medicine Department, State Medical University, Zaporozhye, Ukraine
- *Corresponding Author:
- Alexander E Berezin
Consultant of Therapeutic Unit
Internal Medicine Department
State Medical University of 26, Sedova str
3, Mayakovsky av, Zaporozhye, Ukraine
Tel: 380612894585
E-mail: dr_berezin@mail.ru
Received Date: February 02, 2017; Accepted Date: Apr 26, 2017; Published Date: May 02, 2017
Citation: Berezin AE (2017) Number of Circulating Apoptotic Endothelial Cell-Derived Micro Particles as a Predictor of Metabolically Unhealthy Obesity. J Mol Immunol 2:109.
Copyright: © Berezin AE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Obesity is considered a main factor contributing in diabetes mellitus development and a predictor of CV disease and events. Based on the Adult Treatment Panel-III criteria subjects with established obesity and co-existing other metabolic abnormalities including dyslipidaemia, insulin resistance (IR), increased fasting glucose and impaired glucose tolerance, are referred metabolically unhealthy obesity (Met-UHO), whereas obese individuals without these abnormalities might be defined as metabolically healthy obesity (Met-HO). The mechanisms underlying the change in phenotype from metabolically healthy to metabolically unhealthy obesity are still unclear. It has been postulated that apoptotic endothelial cell-derived micro particles (EMPs) might be a trigger of endothelial cell dysfunction and as well as a mediator on vascular repair. Moreover, the imbalance in circulating number of various types of EMPs may influence the risk of transformation of Met-HO into Met-UHO. The short communication is depicted the role of apoptotic EMPs in obesity phenotype modification.
