Abstract

The management of pain, particularly chronic pain, remains a significant challenge in clinical practice. Traditional analgesic agents, such as opioids and non-steroidal anti-inflammatory drugs (NSAIDs), are associated with considerable side effects and limitations, including the risk of addiction and gastrointestinal complications. The development of novel analgesic agents has been a critical focus in pain management research, aiming to provide effective pain relief with fewer adverse effects. This article reviews the recent advancements in novel analgesic agents, including their mechanisms of action, clinical efficacy, safety profiles, and potential impact on future pain management strategies. Key areas of interest include advancements in biologics, ion channel modulators, non-opioid receptor agonists, gene therapies, and the role of nanotechnology in delivering targeted analgesia.