Abstract

Corneal transplantation, a crucial intervention for vision restoration, is occasionally challenged by the formidable obstacle of allograft rejection. This article delves into the intricate mechanisms underlying corneal allograft rejection, shedding light on the immunological intricacies that contribute to graft failure. By synthesizing current research and clinical insights, we aim to provide a comprehensive understanding of the multifaceted processes involved in this complex phenomenon. From the initial immune response triggered by alloantigens to the downstream inflammatory cascades, we navigate through the storm of rejection mechanisms. Furthermore, the review explores emerging therapeutic strategies and potential interventions that hold promise in mitigating corneal allograft rejection. As we unravel the intricacies of this immunological storm, we hope to pave the way for enhanced clinical management and improved outcomes in corneal transplantation.