Abstract

Malignant osteoid tumors, commonly known as osteosarcomas, present clinicians and researchers with a myriad of challenges due to their intricate nature and potential for aggressive behavior. This article provides an overview of the current challenges encountered in the diagnosis and treatment of malignant osteoid tumors and discusses promising future directions in research and clinical practice. Challenges in diagnosis include the difficulty in distinguishing osteosarcomas from benign bone lesions and the lack of reliable biomarkers for early detection and prognostication. Treatment dilemmas arise from the complexity of achieving negative surgical margins and determining optimal chemotherapy regimens. Looking ahead, future directions in research include advances in molecular profiling techniques for identifying actionable genetic alterations, the investigation of immunotherapeutic approaches, and innovations in drug delivery systems. By navigating the complexity of malignant osteoid tumors, clinicians and researchers aim to improve outcomes and develop personalized therapeutic strategies for these aggressive bone tumors.