Abstract

Morbid obesity poses unique challenges in perioperative management, necessitating a nuanced approach to pharmacological interventions. This abstract delves into the complexities of perioperative pharmacology in morbid obesity, exploring key considerations and strategies for optimizing patient care. Obesity-related physiological changes significantly impact drug pharmacokinetics and pharmacodynamics, requiring careful dosing adjustments to ensure efficacy and safety. Pharmacokinetic considerations, including altered drug distribution and clearance, necessitate individualized dosing regimens based on ideal body weight or lean body mass. Pharmacodynamic alterations, such as increased opioid tolerance and sensitivity to anesthetic agents, further complicate drug selection and dosing strategies. A multidisciplinary approach involving anesthesia providers, surgeons, and pharmacists is essential for navigating perioperative pharmacology in morbid obesity, with emphasis on preoperative assessment, individualized drug therapy, and opioid-sparing anesthesia techniques. By addressing these challenges and considerations, healthcare providers can optimize perioperative outcomes and enhance patient safety in this high-risk population.