Abstract

Drug metabolism, the process by which the body transforms chemical compounds to facilitate their elimination, is a multifaceted phenomenon with significant implications for drug efficacy, safety, and pharmacokinetics. In this abstract, we explore the diverse models and mechanisms employed in the study of drug metabolism, aiming to provide a comprehensive overview of the strategies used to understand its complexities. Mechanistic models elucidate molecular pathways, enzyme kinetics models quantify metabolic rates, pharmacokinetic models integrate metabolism into drug disposition, and systems biology models unite metabolism with broader physiological interactions. Each model offers unique insights into drug metabolism, informing drug design, optimization, and personalized medicine. As researchers navigate the intricate landscape of drug metabolism, understanding the models and mechanisms involved is crucial for advancing pharmacological knowledge and enhancing therapeutic outcomes.