Abstract

It is a chronic childhood disorder with numerous possible causes. Injury to the developing brain during pregnancy or shortly after birth can cause the motor, sensory, and cognitive deficits associated with cerebral palsy. Even though the causes of cerebral palsy vary, neuroinflammation plays a critical role in the pathophysiology of brain injury. Cerebral palsy currently has no effective treatment. Nanomedicine provides a new avenue for research and development of treatments for brain injury that causes cerebral palsy. Dendrimers and other nanomaterials allow multiple drugs to be delivered precisely to the cells responsible for neuroinflammation and injury, reducing the number of injury-related pathways. Furthermore, these materials allow for the delivery of agents that promote brain repair and regeneration, reducing injury and facilitating normal growth. The most recent advances in nanotechnology for the treatment of brain injuries, with a focus on cerebral palsy, are discussed. Possible future directions for making clinical translation easier for children and newborns are also discussed.