Molecular Evaluation of Class 1 Integron in Drug-Resistant Shigella Strains Isolated from Clinical Samples
Received Date: Dec 28, 2022 / Accepted Date: Jan 20, 2023 / Published Date: Jan 25, 2023
Abstract
Background: The aim of this study was molecular investigation of class 1 integron in drug-resistant Shigella strains isolated from clinical samples.
Materials and Methods: 118 samples were collected from the West of Iran. The antibiotic susceptibility, the pattern of antibiotic resistance and investigation the int1 gene was conducted.
Results: From 118 samples taken, 27.12% samples were confirmed as Shigella. Also, 62.5, 21.875, 9.375 and 6.25% as S. sonnei, S. flexneri, S. boydii and S. dysenteria were known, respectively. The highest sensitivity was related to carbapenem and tetracycline (97%) and Shigella has the most resistant to ampicillin (94%). Also, 14 samples (44.8% of the isolates) were found to be positive for the presence of integrase gene. This association was significant for S. flexneri and integron 1 (P = 0.0001).
Conclusion: Carbapenem and tetracycline were the most effective antibiotics. There was also a significant association between integrase 1 gene and MDR strain (P = .00001).
Keywords: Int1 gene; Shigella; Antibiotic Resistance; Carbapenem
Citation: Abdulkareem AA, Lahourpour F, Keshavarzi F(2023) MolecularEvaluation of Class 1 Integron in Drug-Resistant Shigella Strains Isolated fromClinical Samples. Cell Mol Biol, 69: 251. Doi: 10.4172/1165-158X.1000251
Copyright: © 2023 Abdulkareem AA, et al. This is an open-access articledistributed under the terms of the Creative Commons Attribution License, whichpermits unrestricted use, distribution, and reproduction in any medium, providedthe original author and source are credited.
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