Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi Molecular Docking Studies of Coumarin Derivatives as DPPIV Inhibitors and Anti-Diabetic Agents: Towards Novel Approaches in Drug Discovery
*Corresponding Author:Received Date: Jul 28, 2023 / Published Date: Jan 23, 2025
Citation: Sahu L, Mishra A, Sharma G, Verma VS, Sahu G (2025) Molecular Docking Studies of Coumarin Derivatives as DPPIV Inhibitors and Anti-Diabetic Agents: Towards Novel Approaches in Drug Discovery. Int J Res Dev Pharm L Sci 10: 201.
Copyright: © 2025 Sahu L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
Abstract
This study presents the synthesis and evaluation of a series of coumarin derivatives, both standalone and in combination with cinnamic acid, for their potential as Dipeptidyl Peptidase IV (DPPIV) inhibitors and anti-diabetic agents. The compounds were synthesized using established methods and subsequently assessed for their inhibitory activity against DPPIV, a key enzyme involved in glucose regulation. Molecular docking studies were conducted to validate the binding affinity of the compounds with the target protein. The results demonstrated that the synthesized coumarin derivatives exhibited significant DPPIV inhibition and displayed promising anti-diabetic activity. The molecular docking studies supported and reinforced these findings by confirming the favorable binding interactions between the compounds and the DPPIV protein. These results highlight the potential of coumarin derivatives as therapeutic agents for managing diabetes. The findings from this study contribute to the growing body of research on coumarin derivatives and their therapeutic potential. The anti-diabetic activity of these compounds, coupled with their DPPIV inhibitory effects, suggests their potential as effective agents in the treatment of diabetes. These results warrant further exploration and investigation to elucidate the underlying mechanisms of action and to optimize the structure-activity relationship of coumarin derivatives. In conclusion, this study emphasizes the synthesis and evaluation of coumarin derivatives as DPPIV inhibitors and anti-diabetic agents. The molecular docking studies provide valuable insights into the binding interactions of these compounds with the target protein. The promising results obtained from this research support further studies aimed at harnessing the cytotoxic properties of coumarin derivatives for therapeutic applications in the field of drug discovery.
