Abstract

The growing threat of biological hazards, ranging from infectious disease outbreaks to bioterrorism, has underscored the need for flexible and rapid-response solutions in global health security. Portable biocontainment units (PBCUs) have emerged as a key innovation in mobile biosecurity, offering the ability to swiftly contain and manage biological risks in diverse and resource-limited settings. These units are designed to safely isolate hazardous pathogens, protect healthcare workers, and facilitate the containment of both natural and deliberate biological threats. This paper explores the critical role of portable biocontainment technology in enhancing global health safety, focusing on its contributions to pandemic response, bioterrorism prevention, and disaster management. Through advancements in design, mobility, and operational effectiveness, PBCUs are transforming how health systems respond to emerging biological threats. However, challenges remain in terms of accessibility, resource availability, and integration into broader biodefense frameworks. By examining the deployment, innovation, and future prospects of portable biocontainment units, this study highlights their potential to bolster biosecurity efforts and improve health outcomes during crises.