Abstract

Mitochondrial dysfunction/malfunction is an important risk factor for the onset and progression of endothelial cells dysfunction, a key contributor to diabetes mellitus associated cardiovascular disease. The topics discussed here are: (i) The regulatory role of mitochondrial ROS in normal, healthy vascular endothelium, (ii) The adverse alteration of mitochondrial function in diabetes-related endothelial dysfunction, (iii) The endeavors towards correction of mitochondrial malfunction in dysfunctional endothelium, (iv) The key points of mitochondria-targeted interventions in diabetic patients, and (v) The pending, incompletely understood issues that open new basic research directions and may conduct to innovative therapeutic strategies in diabetes.

Keywords: Endothelial dysfunction; Mitochondrial dynamics; Mitochondrial medicine