Journal of Alzheimers Disease & Parkinsonism
Open Access

Research Article

Mitochondrial DNA Haplogroups in Patients with Alzheimer Probable in Guadalajara, Mexico

Genaro Gabriel Ortiz^1*, Verónica Loera-Castañeda¹, Lucila Sandoval-Ramírez², Miguel Ángel Macías-Islas³, Gracia Viviana González- Enríquez¹, Luis J. Flores-Alvarado^1,4, Irma E. Velázquez-Brizuela⁵,
Alfredo Celis de la Rosa⁴ and Fermín P. Pacheco-Moisés⁶

¹Laboratorio de Desarrollo-Envejecimiento; Enfermedades Neurodegenerativas. División de Neurociencias. Centro de Investigación Biomédica de Occidente. Instituto Mexicano del Seguro Social. Guadalajara, Jalisco México

²Laboratorio de Bioquímica IV. División de Genética. Centro de Investigación Biomédica de Occidente. Instituto Mexicano del Seguro Social. Guadalajara, Jalisco. México

³Departamento de Neurología. UMAE-Hospital de Especialidades del Centro Médico Nacional de Occidente. Instituto Mexicano del Seguro Social. Guadalajara, Jalisco. México

⁴Centro Universitario de Ciencias de la Salud. Universidad de Guadalajara, Guadalajara, Jalisco. México.

⁵Instituto Jalisciense de Cancerología OPD-SSA. Guadalajara, Jalisco. México

⁶Departamento de Química, Centro Universitario de Ciencias Exactas e Ingenierías. Universidad de Guadalajara, Guadalajara, Jalisco. México

Corresponding Author:

Genaro Gabriel Ortiz
Laboratorio de Desarrollo- Envejecimiento
Enfermedades Neurodegenerativas
Centro de Investigación Biomédica de Occidente
Instituto Mexicano del Seguro Social
Sierra Mojada 800 cp 43440 Guadalajara, Jalisco, México
E-mail: genarogabriel@yahoo.com

Received date: October 20, 2011; Accepted date: November 09, 2011; Published November 11, 2011

Citation: Ortiz GG (2011) Mitochondrial DNA Haplogroups in Patients with Alzheimer Probable in Guadalajara, México. J Alzheimers Dis 1:103. doi:

Copyright: © 2011 Ortiz GG. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Background and aims . It has been suggested that mitochondrial dysfunction is relevant to Alzheimer disease (AD) and some mitochondrial haplogroups could be related to the risk of AD. Therefore, in this work we have genotyped mtDNA haplogroups in Mexican patients with AD and their respective matched controls. Methods: Haplotyping of 33 AD patients and 49 healthy control subjects was performed using polymerase chain reaction/digest identification of key polymorphic sites in the mitochondrial genome. Results: Mitochondrial haplogroup A is the most frequent in AD patients and controls followed by haplogroup B. The haplogroup C was the least frequent in the control group and it was absent in the AD group. The frequency of haplogroup D was significantly higher in the AD group than in the control group (p = 0.03). Conclusion: There is clear association between the frequency of haplogroup D and Alzheimer disease in the analyzed population from Guadalajara, Mexico. Interestingly the haplogroup C was absent in the AD group. These data requires further study in a larger population to identify these differences more clearly.