Mitochondrial ABC Transporters and Iron Metabolism
Received Date: Feb 03, 2018 / Accepted Date: Feb 12, 2018 / Published Date: Feb 16, 2018
Abstract
Mitochondrial are a key organelle in iron metabolism and many metabolic processes involved in iron homeostasis occur in the mitochondria. Eukaryotic cells have developed different transport mechanisms to deal with coordinating movement of iron and iron-related molecules across membranes. Some of those transport mechanisms involve ATP-binding cassette (ABC) transporters. There are four mitochondrial ABC transporters Abcb6, Abcb7, Abcb8 and Abcb10. Abcb6 is localized to the outer membrane of mitochondria where it is involved in porphyrin transport. Abcb7, Abcb8 and Abcb10 are localized to the inner mitochondrial membrane and the exact molecule transported by each is still unclear. Here, we provide a brief review of what is known about each transporter and its role in mitochondrial iron homeostasis. We describe the human diseases associated with known mutations in the genes encoding these proteins and discuss the possible importance of these transporters in immune cell function.
Keywords: ABC transporters; Mitochondria; Iron; Heme
Citation: Seguin A, Ward DM (2018) Mitochondrial ABC Transporters and Iron Metabolism. J Clin Exp Pathol 8: 338. Doi: 10.4172/2161-0681.1000338
Copyright: ©2018 Seguin A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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