ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
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  • Mini Review   
  • J Infect Dis Ther,
  • DOI: 10.4172/2332-0877.1000533

Mini-review on Evolutionary Dance between Innate Host Antiviral Pathways and SARS-CoV-2

Lulan Wang, Nathaniel A. Sands, Anthony Yu, Heejae Lee, Saba Aliyari and Genhong Cheng*
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, United States
*Corresponding Author : Dr. Genhong Cheng, Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, United States, Email: gcheng@mednet.ucla.edu

Received Date: Jan 24, 2023 / Published Date: Feb 24, 2023

Abstract

Coronaviruses have been circulating in the human population for thousands of years and the human immune system is ineffective in fighting them. However, the innate immune response is a promising avenue for therapeutics against SARS-CoV-2 and other emerging viruses. Deficiencies in innate immune signalling are associated with poor outcomes in SARS-CoV-2 patients, emphasizing the need to understand and harness these mechanisms in the fight against the virus. Innate antiviral strategies range from the direct inhibition of viral components to reprograming the host's own metabolic pathways to block viral infection. The current knowledge of the innate immune signaling pathways triggered by the SARS-CoV-2 with a focus on the type I interferon response, as well as the mechanisms by which SARS-CoV-2 impairs those defenses.

Keywords: SARS-CoV-2; COVID-19 pandemic; Innate immunity; ISGs; Interferon pathways

Citation: Wang L, Sands NA, Yu A, Lee H, Aliyari S, et al. (2023) Mini-review on Evolutionary Dance between Innate Host Antiviral Pathways and SARS-CoV-2. J Infect Dis Ther 11:533. Doi: 10.4172/2332-0877.1000533

Copyright: © 2023 Wang L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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