Abstract

MicroRNAs (miRNAs) have emerged as key players in cancer biology, exerting profound effects on gene expression and cellular processes essential for tumorigenesis and tumor progression. These small non-coding RNAs, typically 18-25 nucleotides in length, regulate gene expression post-transcriptionally by binding to the 3’ untranslated region (UTR) of target mRNAs, leading to mRNA degradation or translational repression. In cancer, dysregulation of miRNAs contributes to the hallmarks of cancer, including sustained proliferation, evasion of apoptosis, angiogenesis, and metastasis.

This comprehensive abstract provides a detailed overview of miRNA networks in cancer therapy, focusing on their molecular insights and therapeutic strategies. It begins by discussing the roles of specific miRNAs in different cancer types, highlighting their dual functions as oncogenes (oncomiRs) and tumor suppressors. The molecular mechanisms through which miRNAs regulate oncogenic pathways are elucidated, emphasizing their intricate roles in modulating signaling cascades critical for cancer cell survival and proliferation.