Methylation Level of ASC/TMS1 and MYD88 Genes in Healthy Larynx and Laryngeal Carcinoma Tissue
Received Date: Oct 02, 2023 / Published Date: Nov 02, 2023
Abstract
Background: There are no biomarkers for diagnosis, prognosis and treatment of patients with laryngeal carcinoma. Methylation changes of ASC/TMS1 and MYD88 genes, in healthy and cancer tissue, might be related with development and progression of cancer. The study explored is there a difference in gene’s methylation in healthy and tumor tissue and does it correlate with protein expression.
Results: The total of 36 patients were enrolled in the study. Methylation of bisulphite converted DNA was quantified by pyrosequencing in fresh frozen cancer and adjacent non-malignant tissues. The overall methylation of MYD88 gene is significantly higher in healthy tissue and this finding correlates with protein expression and the overall methylation of ASC/TMS1 gene is unchanged but the protein expression of ASC/TMS1 is significantly higher in cancer.
Conclusion: The methylation status of the ASC/TMS1 and MYD88 genes are promising prognostic biomarker candidates and may lead to earlier detection of laryngeal cancer.
Keywords: Larynx; Carcinoma; Innate immunity; Genes; Methylation
Citation: Bilić LK, Knežević J, Šutić M, Branica S, Dawidowsky K, et al. (2023) Methylation Level of ASC/TMS1 and MYD88 Genes in Healthy Larynx and Laryngeal Carcinoma Tissue. Diagnos Pathol Open 8:224. Doi: 10.4172/2476-2024.8.3.224
Copyright: © 2023 Bilić LK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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