Journal of Clinical & Experimental Neuroimmunology
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  • Review   
  • J Clin Exp Neuroimmunol,
  • DOI: 10.4172/2376-127X.1000425

Mesenchymal Stromal Cell Uses for Acute Kidney Injury-Current Available Data and Future Perspectives: A Mini Review

Shani Zilberman-Itskovich1* and Efrati Shai2
1Nephrology Division , Assaf-arofeh Medical Center, Zerifin, Israel
2Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
*Corresponding Author : Shani Zilberman-Itskovich, Nephrology Division, Assaf-Harofeh Medical Center, Zerifin, Israel, Tel: +972-509939947, Email: Shani.zilberman@mail.huji.ac.il

Received Date: Feb 21, 2020 / Accepted Date: Mar 04, 2020 / Published Date: Mar 11, 2020

Abstract

There is growing evidence about the potential use of mesenchymal stromal cells (MSCs) for different tissue injuries. Initially, the intended physiological use of MSCs was due to their ability to differentiate and replace damaged cells. However, MSCs have been found to have multiple effects, including being able to significantly modulate immunological responses. MSCs are currently being tested for neurodegenerative diseases, graft versus host disease, kidney injury and other chronic unremitting tissue damage. Using MSCs in acute tissue damage is only now being studied. Acute kidney injury (AKI) is a common cause of morbidity and mortality. After the primary insult, overactivation of the immune system culminates in additional secondary potentially long-standing kidney damage. MSCs have the potential to ameliorate the secondary damage and recent studies have shed important light on their mechanisms of action. This article summarizes the basics of MSCs therapy, the newly discovered mechanisms of action and their potential application in the setting of AKI.

Keywords: Acuterenalfailure , Mesenchymal stemcells , MSC ,  Immuneresponse  , AKI

Citation: Zilberman-Itskovich S (2020) Mesenchymal Stromal Cell Uses for Acute Kidney Injury-Current Available Data and Future Perspectives: A Mini Review. J Clin Exp Neuroimmunol 5: 119. Doi: 10.4172/2376-127X.1000425

Copyright: © 2020 Zilberman-Itskovich S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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