Abstract

Acetaminophen can be effective for mild to moderate pain. Risks of acetaminophen include dose-dependent liver toxicity, especially when the drug is taken at high doses, with alcohol, or by those with liver disease. This risk further illustrates why patients should be aware of the presence of acetaminophen in both over-the-counter and prescribed combination medications. NSAIDs such as aspirin, ibuprofen, and naproxen can provide significant pain relief for inflammation, such as from arthritis, bone fractures or tumors, muscle pains, headache, and acute pain caused by injury or surgery.