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Hindi Mechanisms of Endothelial Dysfunction: The Role of the Renin- Angiotensin Axis, Oxidized LDL, Insulin Resistance, Dyslipidemia, Hyperglycemia, Inflammatory Cytokines, and Autoimmunity
*Corresponding Author:Received Date: Sep 01, 2024 / Published Date: Sep 30, 2024
Citation: Pessoa B (2024) Mechanisms of Endothelial Dysfunction: The Role of the Renin-Angiotensin Axis, Oxidized LDL, Insulin Resistance, Dyslipidemia, Hyperglycemia, Inflammatory Cytokines, and Autoimmunity. Atheroscler Open Access 9: 280.
Copyright: © 2024 Pessoa B. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Endothelial dysfunction is a key factor in the pathogenesis of various cardiovascular diseases. This manuscript explores the intricate mechanisms contributing to endothelial impairment, including the renin-angiotensin axis, oxidized low-density lipoproteins (oxLDL), insulin resistance, dyslipidemia, and hyperglycemia. Additionally, we examine the impact of pro-inflammatory cytokines, adhesion molecules, and autoimmunity on endothelial function. Understanding these mechanisms provides insight into potential therapeutic targets for preventing and managing endothelial dysfunction.
