Manipulating the HIF Pathway in Renal Transplantation, Current Progress and Future Developments
Received Date: Sep 14, 2017 / Accepted Date: Nov 02, 2016 / Published Date: Nov 07, 2016
Abstract
Renal transplantation is the gold standard treatment for end stage renal disease; however, there are currently not enough suitable organs to meet a growing demand. The Hypoxia Inducible Factor (HIF) pathway comprises a number of oxygen sensitive transcription factors which activate cellular protective functions. Allografts from cadaveric organs make up a large proportion of the organ pool. These organs are subjected to hypoxic and ischemic conditions during the harvesting and transplant process. Manipulation of the HIF pathway may reduce organ damage and improve outcomes. This review evaluates the current evidence for the use of the HIF pathway in renal transplantation and also adds new research conducted into the effect on organ metabolism.
Keywords: Transplantation; HIF; Renal; Metabolism
Citation: Hollis A, Patel K, Smith T, Nath J, Tennant D, et al. (2016) Manipulating the HIF Pathway in Renal Transplantation, Current Progress and Future Developments. J Clin Exp Transplant 1: 110. Doi: 10.4172/2475-7640.1000110
Copyright: © 2016 Hollis A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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